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1994-07-02
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Document 0062
DOCN M9470062
TI HIV-1/HIV-2 seronegativity in HIV-1 subtype O infected patients [see
comments]
DT 9409
AU Loussert-Ajaka I; Ly TD; Chaix ML; Ingrand D; Saragosti S; Courouce AM;
Brun-Vezinet F; Simon F; Virology Department, Bichat-Claude Bernard
Hospital, Paris,; France.
SO Lancet. 1994 Jun 4;343(8910):1393-4. Unique Identifier : AIDSLINE
MED/94254523
CM Comment in: Lancet 1994 Jun 4;343(8910):1376
AB Nine patients with atypical HIV-1 western blot profiles were diagnosed
as having HIV-1 subtype O infection. All the patients were living in
France; eight originated from Cameroon and one from France. Lymphocyte
DNA amplification by the polymerase chain reaction was only positive
when HIV-1 subtype O specific primers were used. Preliminary sequence
analysis of amplified products and serological reactivity against a
specific subtype O synthetic env peptide confirmed HIV-1 subtype O
infection. HIV-1/HIV-2 enzyme-linked immunosorbent assays, especially
those based on env peptides or on the sandwich format, can be negative
in HIV-1 subtype O infection.
DE Acquired Immunodeficiency Syndrome/DIAGNOSIS/*MICROBIOLOGY Adult
Blotting, Western Cameroon Enzyme-Linked Immunosorbent Assay France
Gene Amplification Human *HIV Seronegativity
HIV-1/*CLASSIFICATION/GENETICS/IMMUNOLOGY
HIV-2/*CLASSIFICATION/GENETICS/IMMUNOLOGY Middle Age Polymerase Chain
Reaction JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).